ON THE METHOD OF CLINICAL TEST OF ANTIBACTERIAL DRUGS FOR ACUTE CYSTITIS
REPORT I. NATURAL HEALING, TEST PERIOD AND DOSAGE
1978 Volume 69 Issue 1 Pages 15-22
Details
1978 Volume 69 Issue 1 Pages 15-22
Thiamphenicol in four different daily dosages of 1500mg, 750mg, 375mg, and 190mg, and Sulfamethizolum in daily dosages of 3000mg, 1000mg, and 400mg, were administered by dividing the daily dosage into three portions for two days to 65 cases of female acute cystitis caused by E. coli, and their clinical efficacy was studied. The results revealed.
1) In general the findings of patients considerably improved on the first and the second day after the administration of the drugs, in comparison with the findings at the time of first examination.
2) Among the groups to which Thiamphenicol was administered, no dose response was observed in the findings regarding the bacteria in urine and the grade of pyuria.
3) Among the groups to which Sulfamethizolum was administered, the efficacy in the dosage of 400mg was inferior to those in the dosages of 1000 mg and 3000mg, but no significant difference was observed between 1000mg and 3000mg.
4) In comparing the Thiamphenicol group with the Sulfamethizolum group, we found no significant difference between the two groups regarding the bacteriuria, while as to the grade of pyuria the Sulfamethizolum group was slightly better.
From the above mentioned results, the following points were suggested.
a) The clinical tests of antibacterial drugs for acute cystitis should be performed not in comparison with the rate of natural healing, but in comparing among different type and dosage of antibacterial drugs considered to have some efficacy.
b) The evaluation of efficacy may be made one day and/or two days after starting administration. Through shortening of the test period, the ethical requirements would be better satisfied and the accuracy of the test would be increased.
c) It is not always impossible to seek dose response clinically in acute cystitis cases by relatively simple test, and this should be taken into consideration. The minimum dosage required for Thiamphenicol and Sulfamethizolum has been estimated to be considerably smaller than the amount conventionally regarded as an ordinary dosage.
d) Different antibacterial drugs should be compared by taking the dose response into consideration. In other words, drugs should be compared in their respective optimum dosage.
