1978 Volume 69 Issue 2 Pages 227-231
In patients with bladder tumors treated with hydrostatic pressure method, the serial follow-up results of serum α1-antitrypsin values was divided into 3 patterns corresponding to their clinical effects.
In the group with dramatic response, biphasic peaks of α1-antitrypsin levels were demonstrated.
Monophasic curve was obtained in those with satisfactory response. Uneffective group showed no significant variations.
That might be strongly suggestive of intervening of immune mechanism in those with dramatic response.
Variation in α1-antitrypsin levels, as a quantitative index of tumor necrosis would maintain two main estimations. The one includes evaluation of direct effects after hydrostatic pressure treatment and the accuracy of their prognosis. With periodical measurement after various kinds of clinical management, α1-antitrypsin titers might be a useful indicator for prediction of distant metastases, especially to the lungs.
