EFFECTS OF 6-HYDROXYDOPAMINE ON NEUROGENIC BLADDER DYSFUNCTION
Clinical Study
1978 Volume 69 Issue 7 Pages 886-892
Details
1978 Volume 69 Issue 7 Pages 886-892
The Effects of 6-Hydroxydopamine (6-OHDA) was studied on 18 patients, of whom 12 patients with upper motor neuron lesion and six patients with lower motor neuron lesion, suffering from neurogenic bladder with high residual urine. Local injection of 6-OHDA (1mg/kg) was performed cystoscopically at 3, 6, 9 and 12 o'clock positions around proximal urethra throughout the perineum. Cystogram, Cystometrograms and Phenoxybenzamine test (improvement in voiding pattern or reduction of maximum urethral pressure using urethral pressure profile studies) were carried out in each patient.
The following results were obtained:
1) Improvement of voiding pattern was obtained in 10 patients.
2) The achievement of bladder emptying was mainly due to increases of the bladder pressure and was partially related with alpha-adrenolytic effect of chemical sympathectomy by local administration of 6-OHDA, in view of cystograms cystometrograms and phenoxybenzamine test.
3) In 13 patients, blood pressure rose temporarily at the time of injection but, it was restored shortly after treatment. Vesico-ureteral reflux was observed in four patients after local administration of 6-OHDA. Three of them recovered after two months without special therapy. Massive hematuria was observed in two cases. No other significant complications were noted.
