1978 Volume 69 Issue 8 Pages 1068-1078
30mg of Adriamycin (ADM) was administered to eleven patients with bladder tumor by intravesical instillation combined with hydrostatic pressure technique.
The results of the treatment evaluated from cystoscopic findings as well as clinical course were markedly effective in 4 cases, effective in 6 cases and noneffective in 1 case.
Urinary recovery of ADM of the patients treated by intravesical instillation combined with hydrostatic pressure technique (16.6-60.9%) was markedly decreased in comparison with the patients by intravesical instillation alone (63.4-102.4%), although serum concentrations of ADM made no difference between them.
More ADM seemed to be taken in the bladder wall by enhancement with hydrostatic pressure, which was further confirmed by estimating ADM content of several bladder tissue of dogs both with instillation of ADM combined with hydrostatic pressure and instillation of ADM alone.
The new treatment of intravesical instillation of ADM enhanced with adjuvant hydrostatic pressure technique would be advisable for the treatment of the patients with high stage bladder tumor also.
