1979 Volume 70 Issue 1 Pages 7-14
Excretion levels and pattern of amino acids in urine were studied on 79 cases (52 males and 27 females) with calculus in the upper urinay tract, and compared with that obtained on 30 males and 17 females in the non-calculus group, respectively. The results were as follows:
1) No difference was observed on the sorts of free amino acids excreted in urine between both groups.
2) In the 24-hour excretion levels, the total amino acid amounts were not so different in the male subjects of both groups; as to individual amino acids, significant reduction of α-amino adipic acid and a reducing tendency of glycine were observed in the calculus group. In the females, the calculus group showed a significant reduction of the total amino acid amounts as well as of individual amino acid amounts of threonine, asparagine, glycine, cystine, lysine and histidine.
3) As to the excretion pattern, the ratios of phsophoserine, taurine and lysine increased and the ratio of glycine tended to reduce in the males, though the changes were not significant; in the females, the ratios of phosphoserine, taurine, alanine, isoleucine and arginine increased and the ratios of asparagine and glycine tended to reduce: particularly, phosphoserine, alanine, isoleucine and asparagine showed a significant difference statistically.
4) When compared based on the values corrected by the endogenous creatinine clearance over 24h. per 1.48m2 value, the males did not show any difference, but the females in the calculus group exhibited a significant reduction of asparagine and a reduction tendency of glycine.
According to the results described above, particularly the reduction tendency of glycine, an abnormal metabolism of glycine may be assumed in the calculus group.
