THE RELATIONSHIP BETWEEN PLATELET-LIKE BODIES IN URINE AND PERIPHERAL BLOOD FINDINGS

Abstract

The authors have previously reported that platelets and/or cell elements originating from platelets are always contained in urine. (These small bodies were termed “platelet-like bodies in the urine”-U-PLB). The relationship between the U-PLB and the peripheral blood findings of 179 patients displaying various renal functions (75 cases suffering from glomerulonephritis; GN, 12 cases suffereing from so-called idiopathic renal bleeding; IRB, 53 cases suffering from other renal disorders; ORD, 39 cases suffering from miscellaneous disorders; M, and 30 normal cases; H) were examined. Also, endogeneous creatinine clearance (Ccr) and urinalysis have been performed simultaneously. Although the U-PLB counts were variable, the urine of all subjects with various renal functions from healthy adults to patients with chronic renal failure was found to be involved with U-PLB.
The white blood cell (WBC) count in the blood was significantly related to the frequency of the VII th form of U-PLB of the B-group which have 70ml/min>Ccr≥30ml/min out of total cases (positive correlation). Also, the WBC count in the blood was significantly related to the albuminuria of the a-group which have Ccr >70ml/min out of patients with glomerulonephritis, of the b-group which have 70ml/min>Ccr≥30ml/min out of patients with glomerulonephritis, of the total cases suffering from glomerulonephritis (GN group), of patients with other renal disorders than glomerulonephritis and the socalled idiopathic renal bleeding (ORD group), of the A-group which have Ccr>70ml/min out of all subjects, and of all subjects. The WBC count in the blood was significantly related to the WBC count in the urine of b-group and B-group (both positive correlation). These results were suggested to reveal the progress of the renal disorders.
The hemoglobin-value and the hematocrit-value were related to the U-PLB count in 1mm³ of urine of the GN-group (positive correlation). The color index was related to the frequency of I-form U-PLB of the C-group which have Ccr<30ml/min out of all subjects (negative correlation) and to the P-UV/B of the GN-group (positive correlation). However, the red blood cell count in the blood was not related to the U-PLB.
From these experimental results, it is also assumed that the platelet functions, particularly the platelet adhesiveness, are concerned with bath glomerular filtration and the excretion of U-PLB into the urine.