A HISTOLOGICAL STUDY ON URETHRAL STRICTURE

Abstract

A histological study on acquired urethral stricture was done. Besides hematoxylin-eosin staining (HE), periodic acid Schiff staining (PAS), alcian blue staining (AB) and toluidine blue staining (TB) were performed. In the normal glandular tissues of the urethra, PAS positive and also AB positive substances were observed. In the deformed or shrunk glandular tissues on the specimens from urethral stricture, only AB positive and TB metachromatic substances were observed, while PAS positive substances disappeared. The granulomatous tissues were stained strongly with AB and showed metachromasia with TB.
From the observed histological and histochemical changes on the urethral stricture, it is suggested that certain substances with strong acid radicals in the destroyed glandular tissues have some relation to the formation of granulomatous tissue which was observed at the site of urethral stricture.