CORRELATION BETWEEN TYPE OF INFECTION AND CLINICAL EFFICACY OF ANTIMICROBIAL AGENTS ON COMPLICATED URINARY TRACT INFECTIONS
1979 Volume 70 Issue 5 Pages 523-533
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1979 Volume 70 Issue 5 Pages 523-533
We have formerly reported a method of classifying the type of infection in complicated urinary tract infections into six groups according to the efficacy of chemotheapeutics. This time, we investigated the characteristics of each group from a viewpoint of drug efficacy.
In UTI with indwelling catheter and afterprostatectomy, Proteus spp., Serratia and P. aeruginosa were isolated more frequently as infecting organisms than in the other groups, and MIC distribution of each drug in these two groups deviated significantly to resistant side, and also cross infection occurred frequently in cases with indwelling catheter. We believe that is the reason why drug efficacy was so low in these two groups.
Drug efficacy was also low in the cases with mixed infection compared to those of single infection, but the reason why drug efficacy was low in mixed infection was not clear. It was suggested, however, inactivation of drugs, especially penicillins, contributes to the lowering of the efficacy to some extent.
