1981 Volume 72 Issue 3 Pages 271-277
The serum concentration and urinary excretion of uric acid in 205 stone-formers were estimated comparing to those in 145 controls.
The results were as follows:
1) Serum uric acid levels did not show significant difference between both groups, although in stone-formers it tended to increase.
2) Urinary uric acid levels in stone-formers were significantly higher than in controls.
3) Hyperuricosuria was more frequent in stone-formers. The incidence of hyperuricemia, on the other hand, was not different.
4) The characteristics of uric acid disorders in stone-formers described above were observed only in male patients.
These results suggest the possibility that uric acid disorder may play some role in the genesis of nephrolithiasis especially in male patients.
