COAGULUM INSTILLATION AS THE TREATMENT OF BLADDER TUMOR

Abstract

For the purpose of keeping the urinary concentration of anticancerous drugs for longer period, we devised a new method of bladder instillation using fibrin clot (Coagulum) containing anticancerous drugs.
Coagulum was easily made from fibrinogen solution and thrombin solution. It was proved in vitro that bleomycin dissolved in Coagulum was released gradually as coagulum was melted by urokinase in the urine.
Following the above experiment we clinically performed bladder instillation of coagulum containing bleomycin in 12 cases. A certain urinary concentration of bleomycin was maintained for 6-9 hours. There was no harmful side effect except for bladder irritation in cases on local anesthesia.
Histological examination of specimens resected after coagulum instillation showed epithelial denudation with submucosal inflammation, which suggested a strong chemical action of bleomycin for many hours.