1982 Volume 73 Issue 4 Pages 462-468
Local administration of 6-Hydroxydopamine (6-OHDA) into the proximal urethra and bladder base was performed 18 patients suffering from neurogenic bladder dysfunction. The effects of chemical sympathectomy were studied for 43.4 months on the average. Ten cases maintained improved bladder function. Among them, 7 cases showed balanced bladder and remaining 3 cases required additional local injection of 6-OHDA. Two of these improved cases who had bladder deformity and hydropelviureter before the treatment showed improvement in cystometrogram and pyelography. Eight cases showed no improvement in bladder function. VUR was developed in two cases among them and caused deterioration of the upper urinary tracts.
The above results showed the effectiveness of local injection of 6-OHDA to certain cases of neurogenic bladder dysfunction.
