THE EFFECT OF ADRENERGIC DRUGS UPON THE RENAL PELVIC PACEMAKER CONTROLLING THE URETERAL PERISTALSIS

Abstract

The effect of adrenergic drugs upon renal pelvic pacemaker controlling ureteral peristalsis was measured. By using an in vivo experimental model recording renal pelvic pressure and electromyogram with blood pressure, we found that noradrenaline stimulated the rate of ureteral contraction up to the rate of pacemaker rhythm, While isoproterenol depressed the renal pelvic pressure and ureteral contraction, Although, using an vitro method which enabled us to record the electromyograms on the proximal end of the renal pelvis and other part of the pelvis and ureter with renal pelvic pressure changes, we found that isoproterenol decreased the renal pelvic pressure and suppressed the propagation of the pacemaker discharge toward the renal pelvis and ureter, while pacemaker activity was not affected by the isoproterenol administration. As a result, we found that the pelvic pressure did not reflect the pacemaker activity of the proximal end of the pelvis under administration of isoproterenol.