STUDY ON HYDRONEPHROSIS

Urinary Components and Renal Function in Hydronephrosis

Abstract

To obtain information about the recuperative ability of hydronephrosis following release of obstruction, the animal and clinical experiments were carried out. Mongrel dogs with unilateral hydronephrosis caused by total ureteral ligation performed from 3 hours to 15 weeks before and patients with unilateral hydronephrosis were used in this experiment. Urine was collected from both kidneys for determination of sodium, potassium, urea-N and creatinine concentration.
The result obtained from the experiments revealed that the concentration of K, urea-N and creatine in the urine from the hydronephrosis which recuperate the function after release of obstruction were more than 10mEq/l in K, more than 150mg/dl in urea-N and more than 20mg/dl in creatinine, respectively.
Sodium concentration showed no definite tendency, but the excretion fraction ratio of Na was less than 10%.
On comparing the urine from both kidneys, the potassium, urea-N and creatinine concentration in the urine from the hydronephrosis with recuperative ability were more than 20% of that in the urine from control kidney.
The concentration of Na, K, urea-N and creatinine in the urine from the hydronephrosis was nearly as low as that of serum when the renal function was hardly recovered.
Histological examination of the kidney with recuperative ability revealed that cortical glomeruli and tubuli were preserved in relatively good condition in spite of partial damages of medullary tubuli. Because urine was safely and easily aspirated from renal pelvis under ultrasonographic control, measurement of urinary components is a clinically useful method to determine the recuperative ability of hydronephrosis following release of obstruction.