A STUDY ON THE EFFECTS OF BLADDER DISTENTION ON BLOOD
PRESSURE AND PLASMA CATECHOLAMINES
1982 Volume 73 Issue 8 Pages 977-987
Details
1982 Volume 73 Issue 8 Pages 977-987
The effects of fast urinary bladder distention on blood pressure, plasma catecholamines (CA) and plasma renin activity (PRA) were studied in 33 mongrel dogs anesthetized with chloralose. The blood for measurements was obtained from the inferior vena cava and brachial artery. Plasma CA was measured by THI method using Shimazu HLC systems and PRA by radioimmunoassay.
1) Preliminary experiments revealed that blood pressure and plasma CA level were stable during one hour anesthesia, till a 40ml blood loss in total.
2) During rapid bladder distention, blood pressure was significantly increased to 110-120% of the initial level.
3) Accompanying the blood pressure rise, plasma norepinephrine level was also significantly increased to 150% of the initial level.
4) PRA was also increased during bladder distention, but it rose more gradually than plasma CA.
5) The pattern and rate of plasma CA and PRA increase were not characteristic of the evoked blood pressure rise. Therefore, it seemed that plasma CA and PRA might not play the main roles to increase blood pressure.
