1983 Volume 74 Issue 10 Pages 1778-1783
22 patients with high grade invasive bladder cancer were treated with preoperative radiation therapy (910 rad by fast neutron or 3000 rad by X ray during 2 weeks) followed by radical cystectomy and urinary diversion. 62.5% of patients showed reduction in tumor size more than 50% evaluated by cystogram. Stage down was observed in 38% of patients compared between clinical and pathological stage. Histopathological effect of GII or GIII, according to the criteria described by Ohboshi, was noticed in 79% of the patients. Better effect seemed to be obtained in fast neutron treated group than in X ray group.
19 patients received curative operation, and 18 patients are alive without recurrence for 10 months (mean observed term). One has died from lung metastasis 4.5 months after operation. 50% of the patients complained of side effects of irradiation although they were tolerable, and 32% of the patients had major complications of operation.
