STUDIES ON THE APPLICATION OF MICROEXPLOSION TO MEDICINE AND BIOLOGY
VII. Injury to the Dog Bladder by Microexplosion
1983 Volume 74 Issue 3 Pages 299-310
Details
1983 Volume 74 Issue 3 Pages 299-310
In microexplosion cystolithotripsy, it is most important to investigate the degree of damage to the bladder wall and to prevent this damage.
The bladders of 8 dogs excised after sacrifice were used. An originally developed explosive catheter fixed by a special apparatus was used to induce microexplosion at various distances between the explosive chamber at the catheter tip and the bladder wall in air, water or jelly. Macroscopic and histological damage was studied and the amount of lead included in some bladder fragments was measured.
1) The greater the distance from th explosive chamber to the bladder mucosa and the higher the density of the medium, the less was the damage to the bladder wall. It was noted that the bladder fragment remained intact when the distance from the explosive catheter tip to the bladder mucosa was over 1.0cm in water or 0.75cm in jelly.
2) Black deposits observed histologically in the bladder wall contained much lead. The amount of them correlated well with the stage of injury in the bladder.
3) It was thought that the three factors which the determimed the extent of bladder damage from microexplosion were: Shock wave, gas or other reactive products and heat.
(1) The dynamic effect of shock wave from microexplosion might be injurious in air but not in water or jelly.
(2) It was thought that gas and other reactive products were the most imporant factors in bladder damage. However, they were less hazardous in water or jelly than in air, because water or jelly might suppress their movement.
(3) Though burning by heat was not recognized histologically in this experimental study in vitro, heat might be a factor of local damage in air. In water or jelly rapid cooling might prevent the damage.
It is concluded from these results that water or jelly is more suitable than air as the medium for microexplosion cystolithotripsy. Microexplosion will be able to be employed clinically in a water or jelly medium.
