1983 Volume 74 Issue 7 Pages 1248-1251
Mucinous adenocarcinoma arising from the prostate are so rare that only 41 cases have been reported in the literature. The first case of mucinous adenocarcinoma of the prostate which was responsive to chemotherapy is reported.
(Case Report) A 65-year-old male was presented with a one-year history of prostatism and was found to have clinical evidence of intracapsular prostatic tumor. Resected tissue revealed histologic features of mucinous adenocarcinoma of the prostate. Acid and alkaline phosphatase values were within normal limits. The patient was managed by bilateral orchiectomy and with diethylstilbestrol for one year. Then he underwent exploratory laparotomy, cystoprostatectomy and ileal conduit urinary diversion. Histologic examination confirmed mucinous adenocarcinoma of the prostate. Subsequently the patient received irradiation and chemotherapy using 5-fluorouracil and cyclophosphamide. However the disease was progressive. Radionucleotide bone scan revealed osseous metastasis. Partial remission occurred for 80 days with peplomycin (3-[(s)-1'-phenylethylamino] propylaminobleomycin), which is an analogue of bleomycin. He died 3 years after the establishment of diagnosis.
(Comment) The diagnosis of mutinous adenocarcinoma of the prostate was made by histochemical examination and by exclusion of an extraprostatic primary source.
The primary tumor showed histopathological features of mostly mucinous component, partly tubular component and the transitional part between them. It was suggested that this tubular component might produce abundant mucus culminating in the mucinous adenocarcinoma with both muconodular and signet-ring cell pattern.
