1983 Volume 74 Issue 8 Pages 1412-1417
In 28 cases of carcinoma in situ diagnosed histopathologically by TUR biopsy, 10 cases were followed up and treated by bladder instillation method of Bleomycin, Mitomycin and Adriamycin. Two cases of them had to undergo total cystectomy and 4 cases were performed 2nd TUR biopsy and furgulation which showed carcinoma in situ in 3 cases and atypia in one case even after instillation therapy. The urine cytology showed 6 cases returned to positive within 3 months and 3 cases returned to positive in 6 to 12 months. Only one case continued to be negative after 12 months. These results indicate that bladder instillation therapy can not cure carcinoma in situ. Electron microscopic examination of carcinoma in situ showed findings resembling Grade III in the invasive papillary transitional cell carcinoma. Therefore carcinoma in situ will have the same aggresive characteristics as Grade III transitional cell carcinoma even in the state of in situ.
