STUDY ON ENHANCEMENT OF THE PERMEABILITY OF DRUGS TO THE WALL OF THE URINARY BLADDER BY HYPERTHERMIA WITH LIDOCAINE

Abstract

Changes in the membranous permeability of the wall of the urinary bladder were examined in adult mongrel dogs using hyperthermia with anticancerous drugs to which lidocaine had been added. Bleomycin (BLM) was used as an anticancerous drug. As the perfusion solutions in hyperthermia of the urinary bladder, the following 4 kinds of solutions were employed: lidocaine and 60μg/ml BLM, lidocaine and 120μg/ml BLM, 60μg/ml BLM without lidocaine, and 120μg/ml BLM without lidocaine.
The following results were obtained:
1) There was no significant difference in the serum levels of BLM between the groups with and without lidocaine in either the 60μg/ml-BLM or the 120μg/ml-BLM group.
2) BLM levels in the tissues of the wall of the urinary blasser were high in the whole layer and the mucosal layer of the bladder in the group with lidocaine. The difference of the level was particularly significant in the mucosal layer.
These results indicate that the membranous permeability of the wall of the urinary bladder increases due to the addition of lidocaine and easily induces the intake of drugs into the tissues (especially the mucosal layer).