MANAGEMENT OF CHRONIC SPINAL CORD INJURY PATIENTS WITH PRAZOSIN
1983 Volume 74 Issue 9 Pages 1621-1626
Details
1983 Volume 74 Issue 9 Pages 1621-1626
17 patients with chronic spinal cord injury, who have micturitional disturbance either objectively or subjectively, were treated with prazosin. We investigated the effect of prazosin using urodynamic study and various urography. 88% of the patients were objectively improved in micturitional difficulity. Residual urine was remarkably reduced in 70% of the patients. 4 cervical subjects with intense detrusor sphincter dyssynergia showed no response to the administration of prazosin. In three patients out of six with vesicouretral reflux, the reflux disappeared after a week or so. Control of autonomous dysreflexia was noted in one patients. Side effect was recognized in only one case, that was epigastric discomfort.
We postulated the medraism by which a-blocker could abolish the reflux.
