1984 Volume 75 Issue 2 Pages 233-239
Metabolism of vascular protein was investigated by determining the incorporation rate of 3H-proline into the collagen and non-collagenous protein in vasculatures in young genetically hypertensive rats some of which received antihypertensive drugs.
The incorporation of 3H-proline into the collagen or non-collagenous protein in renal artery in 8-week-old spontaneously hypertensive rats (SHR) and in stroke-prone spontaneously hypertensive rats (SHRSP) was significantly greater than that in Wistar Kyoto rats (WKY). Administration of clonidine or phenoxybemzamine (POB) decreased the incorporation of tritiated proline into the collagen and non-collagenous protein in each rat strain, concomitant with a reduction of blood pressure. The incorporation rates of tritiated proline into these fibrous protein fractions were similar in the heart of each rat strain treated with either clonidine or POB. The free 3H-proline radioactivity 2 hrs in serum after the injection of tritiated proline was similar in each examined group.
These results indicate that increased synthesis of collagen and non-collagenous protein in the renal artery in young genetically hypertensive rats is involved in the pathogenesis of development of hypertension.
