A BASEMENT MEMBRANE ANTIGEN ISOLATED FROM RENAL CELL CARCINOMA, AND ITS LOCALIZATION IN THE TISSUE

Abstract

A non-collagenous basement membrane glycoprotein, laminin, was isolated from human renal cell carcinoma as pepsin digested fragments as described by Risteli et al. Immunohistochemical localization of laminin was demonstrated in 32 cases of formalin fixed human renal cell carcinoma using anti human laminin antiserum. The patterns of localization for laminin could be divided into three different types by the homology to normal tubular basement membranes. The clinical features of patients with renal cell carcinoma were closely related to the histochemical patterns of laminin localization.