COMPLETE REGRESSION OF PULMONARY METASTASES FROM RENAL CELL CARCINOMA INDUCED BY MEDROXYPROGESTERONE AND STREPTOCOCCAL PREPARATION: A CASE PRESENTATION
1985 Volume 76 Issue 12 Pages 1909-1913
Details
1985 Volume 76 Issue 12 Pages 1909-1913
A rare case who represented complete regression of pulmonary metastases from renal cell carcinoma induced by medroxyprogesterone acetate (Provera®) and streptococcal preparation (OK-432) is presented.
A 59-year-old man with hemosputum and weight loss was radiographically found to have left renal tumor metastasized to the both lungs and the left adrenal. He underwent radical nephrectomy and was treated with administration of OK-432 and Provera as an adjuvant. Pathological diagnosis of the tumor was alveolar type renal cell carcinoma mainly consisting of clear cells with adrenal metastasis. Transbronchial lung biopsy showed that the pulmonary lesions were metastatic carcinoma. A month after the beginning of oral administration of Provera, 100mg daily, the pulmonary lesions began to regress. A subsequent chest X-P taken 1.5 months later showed complete disappearance of the coin lesions. He had 16 week and additional 8 week administrations of Provera, supplemented with intramuscular OK-432, 5KE/week. At present, 1 year after the nephrectomy, all of laboratory and clinical findings show that he is free from the disease and he is doing as well as he used to be.
