1985 Volume 76 Issue 4 Pages 473-482
The effects of combined chemo-radiation therapy were studied using human urinary bladder cancer (NM-B-1) and human prostatic cancer (Pro-1) transplanted into nude mice. NM-B-1 is a poorly differentiated transitional cell carcinoma and Pro-1 is a poorly differentiated adenocarcinoma. In both the 24th to 27th passage of NM-B-1 and the 35th to 38th passage of Pro-1, the successful transplantation rates were almost 100 per cent and the growth rates were similar and stable. The therapies were performed by intraperitoneal administration of anticancer drug combined with single-dose irradiation using a linear accelerator. Since the sensitivity of each single agent used in this study was already known for NM-B-1 and Pro-1, the therapeutic modalities in doses were planned by combination of doses less than the minimal effective dose of each agent. The therapeutic effects were evaluated on the tumor growth curve, as well as light and electron microscopic findings, and the following conclusions were obtained: I) In the studies using NM-B-1, therapeutic potentiation effects were achieved by radiation combined with CDDP, BLM or PEP on the tumor growth curve. II) In the studies using Pro-1, therapeutic potentiation effects were achieved by radiation combined with CDDP, PEP or 5FU on the tumor growth curve, but not achieved by radiation with MMC. III) In all but the groups treated by radiation with MMC or 5FU, the characteristic changes were a vacuolic and/or exudative destruction of cytoplasm with a stromal edemahyalinosis in the light and electron microscopic findings.
