1985 Volume 76 Issue 4 Pages 516-520
It is important to perform histopathological examination of the endoscopically normal bladder epithelium of patients with bladder tumor, because carcinoma in situ or precancerous lesions may be sometimes found there. For that purpose, we began to develop a new technique of contact-micro-cystoscopy to observe bladder epithelium with high magnification.
As a basic study, we stained the bladder of dogs with methylen blue, toluidine blue, thionine or cresyl violet acetate, and observed with Storz Contact-Micro-Colpohysteroscope 26156B. It is presumed from this trial that cresyl violet acetate may be the best to stain the bladder epithelium. We also stained the epithelium of the bladder with tumor after total cystectomy with cresyl violet acetate, and observed with this instrument. We could find neoplastic changes in bladder epithelium with the naked eyes.
It is thought that contact-micro-cystoscopy may be used clinically after further improvement of this instrument.
