A CASE OF INTERSTITIAL CYSTITIS COMPLICATED WITH ULCERATIVE COLITIS

Abstract

A 29-year-old man with ulcerative colitis was seen complaining of severe urinary urgency. The urinalysis showed numerous red blood cells, a few leucocyte and no bacteria cultured. He had also suffered from bronchial asthma and nasal allergy. Maximum bladder capacity was about 150ml. Some erosions were found by cystoscopy. The specimen of vesical wall revealed prominent eosinophilic and basophilic infiltrations with moderate edema and fibrosis in the subepithelial connective tissue. By the skin test, rag weed, mite, house dust and candida were positive at immediate reaction. IgE RAST score is Rag weed and House dust (2), Mite (3).
On instilation of rag weed extracts into vesical cavity, urinary urgency, diarrhea, cutaneous exanthema, nausea and general fatigue appeared. After provocation, the histamine level in urine increased to a peak after an hour and urinary red blood cell increased gradually. By instilation of steroid into the bladder, the symptoms were relieved and the bladder capacity increased about 250ml.