1986 Volume 77 Issue 3 Pages 501-506
The contractile responses to dobutamine, a beta one adrenoceptor agonist and terbutaline, a beta two adrenoceptor agonist, were examined by measurement of the isometric force in rabbit pelviureteral smooth muscle strips. Dobutamine caused an increase of contractile force in the renal pelvic strip in the presence of phentolamine, an alpha adrenoceptor blocking agent, and a slight decrease in the ureteral strip. Terbutaline caused a decrease of contractile force in renal pelvic and ureteral strips. The responses of pelviureteral strips to dobutamine or terbutaline were inhibited by propranolol, a beta adrenoceptor blocking agent.
These results seem to suggest that beta one adrenoceptors which cause a contraction exist mainly in the renal pelvis and that beta two adrenoceptors which cause a relaxation exist in both the renal pelvis and the ureter.
