EFFECT OF AGEING ON THE RESPONSE OF RABBIT ISOLATED BLADDER DETRUSOR TO PROSTAGLANDIN E1, E2 AND F2α

Abstract

Experiments were done to determine if age-related changes occur in responses of rabbit bladder detrusor to prostaglandins E1, E2 and F2α. The contractile response to prostaglandin E1 was greater in isolated detrusor muscles from mature rabbits than in those from premature rabbits. In contrast, the contractile responses to prostaglandin E2 and F2α were greater in muscles from premature rabbits than in those from mature rabbits. These results suggest that prostaglandins E1, E2 and F2α have an important role in the change of bladder contraction with age.