STATISTICAL OBSERVATION ON OUR BLADDER TUMOR REGISTRY

3. Sex and Prognosis

Abstract

Releations of sex to various clinicopathologic findings of bladder carcinoma in 1120 patients treated at university hospital of Tokyo Medical and Dental University and its related hospitals, were statistically investigated. The overall ratio of male to female was found 3:1; the ratio significantly decreased in patients over 60 years old (p<0.025); and the prognosis or women was significantly poorer than that of men. To explore insight to factors affecting the different prognosis by sex, histologic grade, stage, number and size of the tumors, and treatment modalities were statistically analysed in the present study. Since it has been recognized by statistical analysis of the same patient group in our previous report that patients over the age of 60 years had significantly poorer prognosis than those under 60 years of age, patiants of each sex were divided into two groups by ages over and under 60 years. In the younger group, the difference of the survival rate between male and female was not significant, while in the older group, five years relative survival rate was significantly low in female (56.4%) than male (71.9%) (p<0.05). In patients under 60 years of age, the above factors except for tumor stage revealed no significant difference between male and female; the incidence of invasive tumors (>T2) was significantly higher in female (43%) than male (28%) (p<0.05). In patients older than 60 years, incidences of high grade tumors (grade 3), invasive tumors (>T2) and multiple tumors was found higher in female (42%, 44% and 45%, respectively) than male (35%, 34% and 35%, respectively) (p<0.05). When compared to men, the incidence of the treatment with transurethral resection was low and that of palliative therapy was higher in female patients older than 60 years (p<0.005). Those factors may integrate together and result in poor prognosis of aged women with bladder carcinoma.