1986 Volume 77 Issue 4 Pages 642-645
Many of the studies on nonspecific granulomatous prostatitis are concerned with its histology and only a few deal with its pathogenesis, in particular its bacteriological cansality. Inspired by the report indicating that, in malacoplakia which develops similar granuloma, E. coli is involved in its pathogenesis, we performed immunohistochemical staining, using anti-E. coli antibodies, in 3 cases.
The immunological staining was carried out by Avitin Biotin Peroxidase Complex method, using anti-E. coli antibodies (5 types from serotypes A to E were used). In all of the 3 cases positive staining was observed only with anti-E. coli antibody of serotype C. The staining was found within parenchyma which formed granuloma and within plasma of histocytes which appeared in glandular cavity.
These results strongly indicate the possibility that E. coli is involved in the pathogenesis of non-specific granulomatous prostatitis.
