CLINICAL STUDIES OF METHYLCOBALAMINE (CH₃-B₁₂) FOR OLIGOZOOSPERMIC PATIENTS

Abstract

Methylcobalamin (CH₃-B₁₂) was administered in a dose of 3000μg/day for 3 months to 62 oligozoospermic men with a presumed disturbance in spermatogenesis. Before and after treatment the ejaculate volume, sperum density, total sperm count, sperm motility, total motile sperm count, sperm velocity, bilateral testiculular volume, serum levels of LH, FSH and testosterone and concentrations of Zn, Mg, PAP and vitamin B₁₂ in the seminal fluid were measured. A significant improvement after treatment was revealed in sperm density, total sperm count, sperm motility, total motile sperm count and sperm velocity. Concentration of vitamin B₁₂ in seminal fluid was significantly elevated. Pregnancy occurred in 5 of the 62 partners, 1 of the 5 by AIH.