1986 Volume 77 Issue 5 Pages 822-826
A case of intestinal type adenocarcinoma including paneth cells originating in the bladder was reported.
The patient was a 40-year-old man. His chief complaint was asymptomatic macrohematuria. Cystoscopy found a broad-base tumor in part with ulceration of a size of thumb's head near the apex part of the bladder. The biopsy showed mucous secreting adenocarcinoma. Radiography of the digestive organs showed no abnormality. A broad partial cystectomy was performed for the suspected urachal cancer. Histologically the tumor was limited up to submucosa, that is, pTIb. PAS staining revealed mucous cells similar to those in the intestinal tract. HE staining revealed paneth cells with eosinophilic granules and silver staining revealed the cells with argentaffin granules. Immunohistological staining using muramidase antibody (PAS method) revealed brown stained granules. These findings led to diagnosis of an intestinal type adenocarcinoma originating in the bladder containing paneth cells. Most of paneth cells exist in the proximal Lieberkühn's crypts, the function and physiological significance of which are still uncertain.
The case of intestinal type adenocarcinoma originating in the bladder, where paneth cells were found, was reported for the first time by Pallesen in 1981, and our present case seems to be the second.
