PREOPERATIVE ONE-SHOT INTRAARTERIAL INFUSION CHEMOTHERAPY FOR BLADDER CANCER
2. The Evaluation of Clinical Usefulness of Adriamycin and Cisplatin
1986 Volume 77 Issue 6 Pages 909-913
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1986 Volume 77 Issue 6 Pages 909-913
We investigated the clinical usefulness of pre-operative one-shot intraarterial infusion chemotherapy of ADM and CDDP in patients with urinary bladder cancer.
We performed intraarterial infusion of 30mg ADM in 10 patients and 75mg CDDP in 10 patients from the internal iliac artery.
In 16 patients (ADM 7, CDDP 9), the reduction rate of tumor size could be assessed by means of cystography, cystoscopy and transurethral ultrasonic tomography performed before and 1 week after the infusion, the reduction of tumor size was observed in 6 out of the 7 patients after ADM infusion and in 4 of the 9 after CDDP. The reduction rate≥10% was seen in 5 after ADM and in 4 after CDDP. Among them, the rate≥20% was observed in 4 after ADM and in 1 after CDDP.
In all cases, we assessed the histological effect of these drugs. The injury of tumor cells was seen in 9 out of the 10 patients after ADM and in 9 of the 10 after CDDP. Among them, the destruction of tumor structure was observed in 4 after ADM and in 4 after CDDP.
Our observations demonstrated that one-shot intraarterial infusion chemotherapy of ADM or CDDP was a useful preoperative therapeutic method for urinary bladder cancer.
