1986 Volume 77 Issue 8 Pages 1310-1317
Calcium oxalate crystal formations induced in the rat kidney by intraperitoneal injection of L-Hydroxyproline (L-HP) were studied by optical and scanning electron microscopy (SEM).
After a single injection of L-HP, the crystals in the rat kidney were distributed mainly in proximal tubules, loops of Henle and distal tubules and were rarely observed in collecting tubules.
After injection of L-HP twice a day for a week, the crystals were seen mainly in distal tubules and rarely in proximal and collecting tubules.
Using the SEM technique, denuding of mucous cells, dilation of ducts of Bellini and small sphericles which were considered to be calcium oxalate monohydrate crystals were observed in the papillae. Moreover, lumps consisting of erythrocytes, denuded mucous cells and microfilaments were also observed on the surface of papillae and in the ducts of Bellini.
These lumps are thought to have an important role in fixation and development of calcium oxalate crystals.
