A CASE OF IDIOPATHIC HYPOURICEMIA DUE TO AUGMENTED RENAL TUBULAR SECRETION OF URIC ACID
1986 Volume 77 Issue 8 Pages 1349-1352
Details
1986 Volume 77 Issue 8 Pages 1349-1352
A 74 year-old man with hematuria was found to have a low serum uric acid concentration (1.1mg/dl). The patient passed a uric acid stone and CT scanning revealed a right renal stone.
His uric acid clearance/creatinine clearance (Cur/Ccr) was significantly high. After administration of pyrazinamide 3.0g, Cur/Ccr decreased and serum uric acid concentration increased to the normal level. In response to probenecid administration (1.5g), Cur/Ccr increased markedly. It was suggested that renal tubular secretion of uric acid was abnormaly high in this patient. No other metabolic abnormalities were detected.
The renal stone was dissolved by administration of alloprinol (200mg/day) and sodium bicarbonate (6.0g/day). No side effect was observed.
