THE TUMOR MARKER FOR RENAL CELL CARCINOMA
Evaluation of urine S100-α Protein
1987 Volume 78 Issue 12 Pages 2051-2059
Details
1987 Volume 78 Issue 12 Pages 2051-2059
The clinical usefulness of α subunit of urine S100 protein as a tumor marker for renal cell carcinoma was evaluated in 61patients with renal cell carcinoma, 32patients with other urological cancer, 84patients with benign urological disease and 448healthy volunteers.
Urine S100-α levels were measured by means of a newly established sandwich-type enzyme immunoassay method.
The mean urine S100-α value±SD in healthy volunteers was 0.179±0.121 (ng/ml), and the cut off value (mean+3SD) was 0.542ng/ml. The positive rate of urine S100-α was 63.9% (39/61) for renal cell carcinoma, 15.6% (5/32) for the other urological cancers, and 7.1% (6/84) for benign urological diseases. The urine S100-α levels in patients with renal cell carcinoma were significantly higher than those of healthy volunteers or those with other urological diseases (p<0.01).
The positive rate of urine S100-α for renal cell carcinoma was higher than those of ESR (60.0%), Fibrinogen (51.5%), and IAP (54.5). And the urine S100-α levels in patients with renal cell carcinoma increased as the tumor stage or grade progressed.
Although further study is needed, the urine 5100-α appeared to be a useful tumor marker in diagnosis and staging of the renal cell carcinoma from these results.
