TREATMENT OF MICTURITION DISTURBANCE WITH PRAZOSIN HYDROCHLORIDE
1987 Volume 78 Issue 12 Pages 2168-2172
Details
1987 Volume 78 Issue 12 Pages 2168-2172
The efficacy of prazosin hydrochloride was studied in patients with micturition disturbance. The study was made on a total of 40 patients (33 men and 7 women) with a mean age of 55.0 years. The efficacy was assessed by uning “nomogram” reported by Yachiku et al. calculated from maximum urinary flow rate and urinary volume in urinary flow curves. The result revealed significant improvement (p<0.001) of nomogram score in whole patients ofter administration of prazosis hydrochloride.
When classified by underlying disease, improvement was significant for bladder neck contracture (20), chronic prostatitis (18), and neurogenic bladder (5), whereas no improvement was obtained in patients with benign prostatic hyperplasia (7). This suggests that prazosin hydrochloride may not be expected to work in patients with organic obstruction. In our clinic urethral phentolamine test has been performed as one of routine examinations to differentiate organic obstruction from functional bladder outlet obstruction. Prazosin hydrochloride has been found to be significantly effective in phentolamine-responders. This indicates that the test is a useful means for selection of patients who are expected to repond to prazocin hydrochloride.
