γ-GLUTAMYL TRANSPEPTIDASE ACTIVITIES IN HUMAN RENAL TUMORS
1987 Volume 78 Issue 2 Pages 292-296
Details
1987 Volume 78 Issue 2 Pages 292-296
It has been reported that there is the highest γ-GTP activity of human organs in renal proximal tubular cells. In this article γ-GTP activities in various renal tumors, containing 13 renal cell carcinoma, 1 Wilms tumor, 1 renal haemangioma and 1 renal pelvic tumor, were evaluated by biochemical and histochemical methods. Biochemical study showed that γ-GTP activity of normal renal cortex was highest of all renal tissues examined, and γ-GTP activity of clear cell carcinoma was a quarter of normal renal cortex, but much higher than other tumors. By histochemical examination specific localization of γ-GTP was proved only in normal renal cortex and clear cell carcinoma.
Correlationship between renal tissue and γ-GTP activity was discussed, and it was suggested that granular cell carcinoma might not be originated from proximal tubules but from other tissues.
