1987 Volume 78 Issue 2 Pages 335-340
Two channel-balloon occluded arterial infusion of Cis-diaminedichloroplatinum (CDDP) using angiotensin II (two-channel-BOAIA) was attempted in 17 patients with bladder cancer. The anticancer agent infused was mostly CDDP. Thirteen patients were objectively evaluated and the response rate was 77%. All effective cases seemed to respond to only one shot treatment of 90 to 165mg/body (mean 137mg/body) CDDP. Curative transurethral resection (TUR-Bt) for advanced bladder cancer in 5 cases was perfectly carried out because of tumor size reduction and downstaging by the treatment.
The technique was safe and time saving. No major side effect was noticed. Excellent antitumor effect was obtained by lower total doses of CDDP in this series than used in the conventional method. This therapy is thought to be useful for inoperable cases with advanced bladder cancer.
