STUDIES OF HETEROTRANSPLANTATION OF TRANSPLANTABLE HUMAN UROGENITAL MALIGNANT NEOPLASMS

Part VIII. Chemotherapy for Human Wilms' Tumor Transplantable to Nude Mice

Abstract

Chemotherapeutic effects of anticancer drugs were studied using human Wilms' tumor transplantable to nude mice. Tumor fragments were implanted subcutaneously into nude mice. Drugs were singly administered in schedule of q4d×3 when the estimated tumor weight reached from 100 to 300mg. The drugs used for the experiments were actinomycin D (ACTD), vincristine (VCR), cyclophosphamide (CPA), cisplatin (CDDP), and carboplatin (CBDCA). The doses of drugs for total administration were LD₅₀, 1/2 LD₅₀, 1/4LD₅₀ and 1/8LD₅₀ for mice. Chemotherapeutic effects were evaluated by retardation of tumor growth and histological findings. Significant effects of retardation of tumor growth were seen at the doses of LD₅₀ and 1/2LD₅₀ with all drugs, and at the dose of 1/4LD₅₀ with ACTD, VCR and CPA. Histological effects were seen at the dose of LD₅₀ with ACTD, VCR, CPA and CDDP, and at the dose of 1/2LD₅₀ with CPA. Histological effects were not always in parallel to effects of retardation of tumor growth.