COMPLETE REGRESSION OF PULMONARY METASTASIS FROM RENAL CELL CARCINOMA FOLLOWING TREATMENT WITH UFT

Abstract

One case of histologically verified renal cell carcinoma with pulmonary metastasis that attained complete regression by UFT was reported. The patient was a 57-year-old man. He was asymptomatic, but by physical examination an abnormal shadow of the left lung was pointed out. From the results of examinations, the patient was diagnosed to have pulmonary metastasis of renal cell carcinoma. He underwent redical nephrectomy. The pathological diagnosis was renal cell carcinoma of mixed subtype, grade 3, pT₃N₂. For the pulmonary lesion, transbronchial biopsy was performed and pulmonary metastasis of renal cell carcinoma was verified. As an adjuvant therapy, interferon was administered with no response. Therefore, a treatment with UFT at 3 capsules (300mg)/day was started 5 months postoperatively. On the 69th day of this treatment, partial regression was seen for pulmonary metastasis and complete regression on the 158th day. After that he received UFT continuously. At lyear and 5months after the operation complete regression of the pulmonary metastasis had persisted for 7 months. He has survived with no relapse till now.