1987 Volume 78 Issue 9 Pages 1496-1502
The tissue distribution of hematoporphyrin derivatives (HPD) was investigated 48hours after intravenous administration of HPD, using the bladders removed at radical cystectomy and compared with bladder mapping results.
Spectrophotometrically, a fluorescence emission spectrum with two peaks at 630 and 690nm compatible to that of HPD was observed in bladder tumor tissues including carcinoma in situ (CIS) and epithelial dysplasia. The intensity of HPD fluorescence in the visible tumor such as invasive or noninvasive papillary tumors was larger than that of CIS.
The macroscopic distribution of HPD red fluorescence on the mucous surface of the resected bladder, emitted with UV exposure, was in close accordance with the areas of the cancer and precancerous lesions revealed by histological mapping of the bladder.
These findings indicate that HPD distributes or accumulates in dysplastic and neoplastic transitional cell epithelium and HPD can be an effective photosensitizer for diagnosis and treatment of CIS of the bladder.
