STUDIES OF ANTICANCER DRUGS ADHERING TO BLADDER MUCOSA FOR THE TREATMENT OF BLADDER CANCER

Abstract

Intravesical injection treatment for bladder cancer is being used all over the world. Practically speaking, most of the drugs used are water-soluble, which are eliminated with urine from the body in a short time. Therefore, we developed two kinds of reagents, adriamycin (doxorubicin) emulsion and hydroxyl propyl cellulose (HPC) adriamycin which would remain in the bladder long enough as an anticarcinogen.
How long the reagents could adhere to the bladder mucosa was examined in the rat.
1) There was no difference between the emulsion adriamycin solution and conventional adriamycin solution.
2) The HPC-adriamycin solution could be detected from the bladder tissue of rat injected 4 days before, but conventional adriamycin solution was not found in the bladder tissue.
It is suggested that HPC-adriamycin is expected as very effective therapy for bladder carcinoma.