CHEMOSENSITIVITY TEST AGAINST UROGENITAL MALIGNANT TUMORS TRANSPLANTED INTO NUDE MICE BY THE SUBRENAL CAPSULE ASSAY
1988 Volume 79 Issue 10 Pages 1633-1638
Details
1988 Volume 79 Issue 10 Pages 1633-1638
The chemosensitivity test was carried out by the subrenal capsule assay (SRCA) against a urinary bladder cancer and a prostatic cancer in humans, transplanted into nude mice (NM-B-1 and PRO-1). It was proved that athymic, nude mice were more suitable hosts of the SRCA in my previous experience. Therefore, I used them in this study.
Nude mice tansplanted with NM-B-1 and PRO-1 were treated with 10 various anticancer drugs. The sensitivity was evaluated by the tumor growth inhibition rate (TGIR) on day 11. Anticancer drugs which showed more than 50% TGIR were considered to be sensitive. On NM-B-1, 254-S was the most sensitive drug, while Ifosfamide, Mitomycin C, Bleomycin, Methotrexate and Vinblastin revealed negative sensitivity. On PRO-1, Cisplatin, Mitomycin C and Adriamycin were more sensitive drugs, but only Peplomycin displayed negative sensitivity.
Histological analysis will be also very important to evaluate the sensitivity of anticancer drugs in the SRCA.
