1988 Volume 79 Issue 10 Pages 1663-1668
Although clean intermittent self-catheterization is of value for treatment of dysfunction of the urinary bladder and has been adopted in many clinics, few studies have reported how to keep the catheter sterile and adequate for clinical use with systemic bacteriological examination. This paper reports bacteriocidal effect of Povidon iodine, Chlorhexidine digluconate and Benzalkonium chloride at various concentrations against four species of bacteria: E. coli, S. marcescens, P. aeruginosa and S. aureus cultured from urine and hematoma of patients in our clinic. Chlorhexidine digluconate, at 0.05 pervent, failed to impede the growth of S. aureus. However, a solution of 0.1 percent of Povidone iodine sterilized all samples of bacteria solution, which contained 108 to 109cfu/ml. Among several lubricants for comfortable introduction of the catheter into the urinary bladder glycerin was the best, since it was safe, hydrophilic, and low in cost and a good soluvent for Povidone iodine. Glycerin solution with 0.1 percent of Povidone iodine was prepared as a sterilizing lubricant of the catheter. However, acutal content of effective iodine in glycerin solution was revealed to vary depending on procedures of preparing the solution. The content of effective iodine was 28.4 percent of the theoretical value when the glycerin solution was autoclaved after mixing with Povidone iodine, while it was 83 percent of the theoretical value when glycerin was autoclaved prior to adding Povidone iodine. The value of the iodine content was stable in clinical use thereafter. Glycerin solution with 0.1 percent of Povidone iodine is of use for self-catheterization because of its sterilizing, lubricant and stable character.
