1988 Volume 79 Issue 11 Pages 1745-1750
At the Chiba University Hospital and Asahi General Hospital between 1979 and 1986, 1266 cases of benign prostatic hypertrophy were treated by prostatectomy (mainly retropubic) (643 cases) or transurethral resection of the prostate (TURP) (623 cases), and their histological examinations were performed. Twenty-six cases (4.0%) of incidental carcinoma were detected by prostatectomy; 13 and 13 cases were in stage A1 and A2, respectively. Forty-seven cases (7.5%) of incidental carcinoma were detected by TURP; 26 and 21 cases were in stage A1 and A2, respectively. As a result, 73 cases (5.8%) of incidental carcinoma were detected; 39 and 34 cases were in stage A1 and A2, respectively. There were no differences between the mean age of stage A1 and that of A2. The mean weight of specimens categorized as A2 seemed to be large when compared with that as A1, but no differences were noticed. The mean weight of specimens obtained by TURP in A1 was similar to that in A2. The grade in A2 were 47%, 47% and 6% in the order of highly, moderately and poorly differentiated adenocarcinomas. Four cases of A2, 3 moderately and 1 poorly differentiated, progressed into clinical carcinoma; 3 of which had no treatment postoperatively and the last one received inadequate endocrine therapy. In these cases, the mean period between diagnosis of A2 and clinical carcinoma was 3 years. In A2 that received full treatments, no clinical carcinomas were found up to 8 years. On the contrary, A1 cases showed no progression irrespective of the presence or absence of treatments. It is concluded that stage A2 should be treated further, while A1 may be observed without treatment.
