DENERVATION SUPERSENSITIVITY OF THE RABBIT URINARY BLADDER

Response to Calcium, Acetylcholine, Prostaglandin and Serotonin

Abstract

We investigated in vitro the contraction-response relationship of the denervated rabbit bladder to Ca⁺⁺, acetylcholine, prostaglandin, F_2α and serotonin.
1) Bladder weight and bladder capacity significantly increased one week after denervation.
2) Denervation supersensitivity to Ca⁺⁺ was present, which seemed to be accounted for by an increase of the calcium influx through a voltage dependent Ca channel.
3) Supersensitive response to acetylcholine was observed one week, not two weeks, after denervation.
4) Denervation supersensitivity to prostaglandin F_2α was not observed.
5) Denervation supersensitivity of a detrusor muscle to serotonin was observed.