1988 Volume 79 Issue 4 Pages 713-718
We evaluated Thomsen-Friedenreich antigen (T-Ag) and tumor-specific soybean agglutinin antigen (SBA-Ag) in 63 patients, who had transurethral resection for bladder cancer. All patients were followed up for at least 3 years. T-Ag was detected by the immunofluorescience method using monoclonal antibodies against T-Ag, which was isolated from human erythrocytes.
Tumor-specific SBA-Ag was detected by SBA-FITC after blocking with type O serum and anti T monoclonal antibodies.
The G3/G1-3 ratios of T-Ag positive tumors or cryptic T-Ag positive tumors, which presented T-Ag only after neuraminidase treatment, were 5.6% or 6.7%, respectively. On the other hand, G3/G1-3 ratio of the tumors which showed neither T-Ag nor criptic T-Ag was 46.7%. Thus, the T-Ag expression and the histological grades were correlated significantly (p<0.05). The T-Ag negative and cryptic T negative tumors had a higher risk for recurrence than others.
The SBA-Ag expression was correlated with the histological grades, although it was statistically not significant. T-Ag and SBA-Ag negative tumors seemed to have very high possibility of recurrence.
These data indicate that combination of the two marker expression (T-Ag and SBA-Ag) may help clinicians predict the prognosis of urothelial tumors.
