A STUDY ON URINARY TPA IN BLADDER CANCER
1988 Volume 79 Issue 8 Pages 1337-1347
Details
1988 Volume 79 Issue 8 Pages 1337-1347
Tissue polypeptide antigen (TPA) is an antigenic polypeptide occurring in the membranes of human cancer cells and can be demonstrated in serum and urine by the Prolifigen TPA (125I) Radioimmunoassay.
Urinary TPA (U-TPA) values were measured in 170 patients with bladder cancer, 20 with renal cancer, 10 with renal pelvic & ureteral cancer, 34 with prostatic cancer, 22 with benign prostatic hypertrophy, 27 with urolithiasis, 4 with renal failure, 37 with other urological benign diseases and 54 healthy controls.
The mean values of U-TPA were 152.6U/L and 177.8U/g.Cr. with Cr. adjustment in the control group. The cut off levels of U-TPA were determined as 370.2U/L (Mean±2S. D.) and 534U/g. Cr. (Mean±2S. D.) with Cr. adjustment.
In my basic study, there was no significant difference in random urine samples and 24-h urine samples, with or without pH and/or Cr. adjustment.
The positive rate of U-TPA in 82 bladder cancer patients was 64.6% compared with 61.0% by urinary cytology, and the combination of both was elevated to 79.3%.
The determination of U-TPA seemed to be useful in the screening and the monitoring of bladder cancer.
