1988 Volume 79 Issue 8 Pages 1372-1378
Using human renal cell carcinoma heterotransplanted in nude mice (strain nomenclature, JRC 11), effects of the combined use of hyperthermia and interferon (natural human interferon-alpha; IFN-alpha, 1×105, 3×105 I. U., i. m., and recombinant interferon-gamma; IFN-gamma, 3×105, 6×105 J. R. U., i. p.) were examined. The hyperthermic device used was the Clini-Therm, Mark VII, 915MHz, microwave. IFN administration was started immediately before hyperthermia and carried out on consecutive days. Combined use of hyperthermia and IFN was compared with hyperthermia or IFN alone. Combined use of hyperthermia and IFN-alpha was shown to have significant anti-tumour effects compared with either alone. Of 10 nude mice (10 implanted tumours) used for the experiment, 5 showed complete disapperance of the implanted tumours and the others showed evident prolongation of survival. However, the combined treatment with IFN-gamma and hyperthermia showed no significant effects compared with other treatment groups. Therefore, combined treatment with local hyperthermia and IFN-alpha is suggested to be useful for clinical application to renal cell carcinoma.
